Abstract: This study investigated the awareness, understanding, and attitudes toward green chemistry principles (GCP) among 326 senior high school (SHS) students in Winneba, Ghana. Using a descriptive cross-sectional survey, data were collected from three schools via a validated questionnaire covering demographics, GCP knowledge, sources of information, and attitudes toward sustainable practices. Using SPSS for the data analysis, the study revealed a significant increase in GCP knowledge with academic level, with SHS 3 students outperforming lower levels, but no significant differences by gender or age. Students showed strong understanding of foundational principles such as “Prevent Waste,” but weaker grasp of advanced concepts like maximizing atomic economy and catalysis application. Classroom instruction was the primary source of knowledge, followed by television/radio and textbooks. Attitudes toward green chemistry were overwhelmingly positive, indicating readiness for curriculum integration. Findings emphasize the need for earlier and more practical GCP instruction, integration of multimedia resources, and equitable outreach.