Abstract: Tigray’s displacement situation, as well as past traumas experienced by affected people, intensified the risk of Post-Traumatic Stress Disorder (PTSD) among women after the Tigray conflict (2020–2022). The purpose of this study was to find the relation between the effects of the war and prevalence of PTSD among adult female IDPs at an IDP Centre in Mekelle, Tigray, Ethiopia. In particular, it examined the nature of war experiences, the frequency and intensity of PTSD symptoms, the relationship between war experiences and PTSD symptom clusters, and coping strategies used by displaced women. A convergent parallel mixed methods design was used, based on Feminist Theory and Maslow’s Hierarchy of Needs. Data were gathered from 193 women randomly selected and six purposively selected case workers in in-depth interviews. Quantitative data were analysed using descriptive statistics, Pearson correlation and multiple linear regression, while qualitative data were analysed by directed content analysis. Almost all respondents had experienced multiple types of violence: direct violence, witnessed violence, sex and gender-based violence, traumatic loss and deprivation from displacement. The PCL-5 cut-off for probable PTSD was met by 99.5% of respondents. Displacement deprivation was the consistent predictor of intrusion, avoidance and overall PTSD severity, while witnessing violence and traumatic loss predicted intrusion when controlling for other exposures. Coping strategies included individual, spiritual, social and institutional resources, and lower symptom severity was associated with informal social support. The results indicate that psychosocial screening should be part of general health services and community coping resources should be formally recognised in mental health programmes for women in conflict-affected settings.